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Article

Cell Fusion Connects Oncogenesis with Tumor Evolution.

The American journal of pathology - 1 Jul 2015

Zhou Xiaofeng, Merchak Kevin, Lee Woojin, Grande Joseph P, Cascalho Marilia, Platt Jeffrey L

Abstract excerpt

Cell fusion likely drives tumor evolution by undermining chromosomal and DNA stability and/or by generating phenotypic diversity; however, whether a cell fusion event can initiate malignancy and direct tumor evolution is unknown. We report that a fusion event involving normal, nontransformed, cytogenetically stable epithelial cells can initiate chromosomal instability, DNA damage, cell transformation, and...

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Identifiers

PMID: 26066710
DOI: 10.1016/j.ajpath.2015.03.014
PMCID: PMC4483464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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