Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1

13 Nov 2019

Abstract excerpt

Abstract Increased DNA damage repair is one of the mechanisms implicated in cisplatin resistance. Our previous study indicated that the deregulation of let-7e promoted cisplatin resistance and that let-7e could suppress DNA double-strand break repair in ovarian cancer. In this study, we further characterized the role of let-7e in DNA damage repair and cisplatin resistance in ovarian cancer, and investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics and Chromatin Dynamics
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31722968
DOI: 10.1158/1541-7786.mcr-18-1369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1PMID 31722968Read ↗

Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repairSemantic proximity Read ↗

Let-7i Reduces Aggressive Phenotype and Induces BRCAness in Ovarian Cancer CellsSemantic proximity Read ↗

MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2Semantic proximity Read ↗

miR-7-5p overexpression suppresses cell proliferation and promotes apoptosis through inhibiting the ability of DNA damage repair of PARP-1 and BRCA1 in TK6 cells exposed to hydroquinoneSemantic proximity Read ↗

Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase etaSemantic proximity Read ↗

Let‐7e enhances the radiosensitivity of colorectal cancer cells by directly targeting insulin‐like growth factor 1 receptorSemantic proximity Read ↗

MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell linesSemantic proximity Read ↗

APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic targetSemantic proximity Read ↗

Let-7b expression determines response to chemotherapy through the regulation of Cyclin D1 in GlioblastomaSemantic proximity Read ↗

Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancerSemantic proximity Read ↗

Inhibition of DNA ligase IV affects the DNA damage repair pathway and decreases the sensitivity of olaparib to platinum-sensitive BRCA wild-type ovarian cancerSemantic proximity Read ↗

Let‐7 modulates acquired resistance of ovarian cancer to Taxanes <i>via</i> IMP‐1‐mediated stabilization of multidrug resistance 1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.