Article
CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection.
Frontiers in immunology - 1 Jan 2021
Reilly Emma C, Sportiello Mike, Emo Kris Lambert, Amitrano Andrea M, Jha Rakshanda, Kumar Ashwin B R, Laniewski Nathan G, Yang Hongmei, Kim Minsoo, Topham David J
Abstract excerpt
CD8 T cell memory offers critical antiviral protection, even in the absence of neutralizing antibodies. The paradigm is that CD8 T cell memory within the lung tissue consists of a mix of circulating TEM cells and non-circulating TRM cells. However, based on our analysis, the heterogeneity within the tissue is much higher, identifying TCM, TEM, TRM, and a multitude of populations which do not perfectly fit these...
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