Article
Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue.
Frontiers in immunology - 1 Jan 2021
Doyle Chloe M, Vine Erica E, Bertram Kirstie M, Baharlou Heeva, Rhodes Jake W, Dervish Suat, Gosselink Martijn P, Di Re Angelina, Collins Geoffrey P, Reza Faizur, Toh James W T, Pathma-Nathan Nimalan, Ahlenstiel Golo, Ctercteko Grahame, Cunningham Anthony L, Harman Andrew N, Byrne Scott N
Abstract excerpt
The human intestine contains numerous mononuclear phagocytes (MNP), including subsets of conventional dendritic cells (cDC), macrophages (Mf) and monocytes, each playing their own unique role within the intestinal immune system and homeostasis. The ability to isolate and interrogate MNPs from fresh human tissue is crucial if we are to understand the role of these cells in homeostasis, disease settings and...
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