Article
New insights into the genetics of multiple sclerosis.
Journal of rehabilitation research and development - 1 Jan 2000
Baranzini Sergio E, Oksenberg Jorge R, Hauser Stephen L
Abstract excerpt
Tissue injury in multiple sclerosis (MS) results from an abnormal immune response to one or more myelin antigens that develop in genetically susceptible individuals after exposure to a causal agent that is yet undefined. The genetic component of MS etiology is believed to result from the action of several genes of moderate effect. The incomplete penetrance of MS susceptibility alleles probably reflects...
Topics
- Female
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Humans
- Incidence
- Male
- Multiple Sclerosis
- Pedigree
- Prognosis
- Risk Assessment
