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Validation of a next-generation sequencing assay for the detection of EGFR mutations in cell-free circulating tumor DNA.

Experimental and molecular pathology - 1 Dec 2021

Stitz Regina, Buder Anna, Silye Rene, Baumgartner Bernhard, Pühringer Franz, Filipits Martin, Oberndorfer Eva, Heitzer Ellen

Abstract excerpt

Detection of EGFR mutations from blood plasma represents a gentle, non-invasive alternative to rebiopsy and can therefore be used for therapy monitoring of non-small-cell lung cancer (NSCLC) patients. The aim of this project was to investigate whether the Reveal ctDNA™ 28 NGS assay (ArcherDX, Boulder, CO), has a comparable sensitivity and specificity to droplet digital PCR (ddPCR, gold-standard) and is therefore...

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PMID: 34560086
DOI: 10.1016/j.yexmp.2021.104685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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