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Article

Quantification of mutant alleles in circulating tumor DNA can predict survival in lung cancer.

Oncotarget - 12 Apr 2016

Yang Xue, Zhuo Minglei, Ye Xin, Bai Hua, Wang Zhijie, Sun Yun, Zhao Jun, An Tongtong, Duan Jianchun, Wu Meina, Wang Jie

Abstract excerpt

PURPOSE: We aimed to investigate the feasibility of droplet digital PCR (ddPCR) for the quantitative and dynamic detection of EGFR mutations and next generation sequencing (NGS) for screening EGFR-tyrosine kinase inhibitors (EGFR-TKIs) resistance-relevant mutations in circulating tumor DNA (ctDNA) from advanced lung adenocarcinoma (ADC) patients. RESULTS: Detection limit of EGFR mutation in ctDNA by ddPCR was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26989078
DOI: 10.18632/oncotarget.8021
PMCID: PMC4991494

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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