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Article

The Advantage of Targeted Next-Generation Sequencing over qPCR in Testing for Druggable EGFR Variants in Non-Small-Cell Lung Cancer.

International journal of molecular sciences - 19 Jul 2024

Szpechcinski Adam, Moes-Sosnowska Joanna, Skronska Paulina, Lechowicz Urszula, Pelc Magdalena, Szolkowska Malgorzata, Rudzinski Piotr, Wojda Emil, Maszkowska-Kopij Krystyna, Langfort Renata, Orlowski Tadeusz, Sliwinski Pawel, Polaczek Mateusz, Chorostowska-Wynimko Joanna

Abstract excerpt

The emergence of targeted therapies in non-small-cell lung cancer (NSCLC), including inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase, has increased the need for robust companion diagnostic tests. Nowadays, detection of actionable variants in exons 18-21 of the EGFR gene by qPCR and direct DNA sequencing is often replaced by next-generation sequencing (NGS). In this study, we evaluated the...

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PMID: 39063150
DOI: 10.3390/ijms25147908
PMCID: PMC11277480

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