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Article

Protective Effects of Statin Therapy in Cirrhosis Are Limited by a Common SLCO1B1 Transporter Variant.

Hepatology communications - 1 Oct 2021

Merkel Melissa, Schneider Christina, Greinert Robin, Zipprich Alexander, Ripoll Cristina, Lammert Frank, Reichert Matthias C

Abstract excerpt

Complications of cirrhosis and portal hypertension (PH) can be reduced by statin therapy. The common loss-of-function variant p.V174A in the solute carrier organic anion transporter gene 1B1 (SLCO1B1) gene encoding the organic anion transporting polypeptide 1B1 results in decreased hepatic uptake of statins. Our specific aim was to assess the impact of this variant in patients with cirrhosis and statin treatment...

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Identifiers

PMID: 34558822
DOI: 10.1002/hep4.1753
PMCID: PMC8485882

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