Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients.

International journal of molecular sciences - 6 Oct 2022

Gil-Gómez Antonio, Rojas Ángela, García-Lozano María R, Muñoz-Hernández Rocío, Gallego-Durán Rocío, Maya-Miles Douglas, Montero-Vallejo Rocío, Gato Sheila, Gallego Javier, Francés Rubén, Soriano Germán, Ampuero Javier, Romero-Gómez Manuel

Abstract excerpt

A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced fibrosis and cirrhosis. In this study, we aimed to evaluate the prognosis of cirrhotic patients harboring this variant. We performed a retrospective analysis on 483 prospectively recruited patients from four...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 17-Hydroxysteroid Dehydrogenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Albumins

Share to Liver Cirrhosis

Share to Loss of Function Mutation

Share to Non-alcoholic Fatty Liver Disease

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 36233142
DOI: 10.3390/ijms231911840
PMCID: PMC9569581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients.PMID 36233142Read ↗

Impact of HSD17B13 rs72613567 genotype on hepatic decompensation and mortality in patients with portal hypertension.Semantic proximity Read ↗

High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase–Lowering Effect of a HSD17B13 VariantSemantic proximity Read ↗

A 17‐Beta‐Hydroxysteroid Dehydrogenase 13 Variant Protects From Hepatocellular Carcinoma Development in Alcoholic Liver DiseaseSemantic proximity Read ↗

Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis and adverse liver outcomes: Results from a multi-ethnic Asian cohort.Semantic proximity Read ↗

The rs72613567:TA polymorphism in HSD17B13 is associated with survival benefit after development of hepatocellular carcinoma.Semantic proximity Read ↗

Association of HSD17B13 rs72613567: TA allelic variant with liver disease: review and meta-analysis.Semantic proximity Read ↗

Genetic variant rs72613567 of HSD17B13 gene reduces alcohol-related liver disease risk in Chinese Han population.Semantic proximity Read ↗

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.Semantic proximity Read ↗

Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic TargetSemantic proximity Read ↗

Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol MisusersSemantic proximity Read ↗

Association of HSD17B13 rs72613567: TA Allelic Variant With Liver Disease: Review and Meta-AnalysisSemantic proximity Read ↗

Genetic variation of HSD17B13 is associated with an increased risk of lean nonalcoholic fatty liver diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.