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Article

The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization

23 Sept 2021

Abstract excerpt

Significance We show that Bouncer’s homolog in mammals, SPACA4, is required for efficient fertilization in mice. In contrast to fish, in which Bouncer is required for female fertility, SPACA4 is expressed exclusively in the sperm and is required for male fertility. SPACA4 and Bouncer present an intriguing example of homologous proteins that both play key roles in reproduction yet diverged in terms of gene...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 34556579
DOI: 10.1073/pnas.2108777118

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