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Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer

23 Sept 2021

Abstract excerpt

INTRODUCTION: The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis and mitochondrial respiration. This duality of MYC underscores the importance of further investigation into its role in SCLC metabolism and could lead to insights into metabolic targeting approaches. METHODS: We...

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PMID: 34556188
DOI: 10.1186/s40170-021-00270-9

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