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Article

Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of Salmonella enterica Serovar Typhimurium Infection in Human Macrophages.

Frontiers in immunology - 1 Jan 2021

van Doorn Cassandra L R, Schouten Gina K, van Veen Suzanne, Walburg Kimberley V, Esselink Jeroen J, Heemskerk Matthias T, Vrieling Frank, Ottenhoff Tom H M

Abstract excerpt

Global increases in the prevalence of antimicrobial resistance highlight the urgent need for novel strategies to combat infectious diseases. Recent studies suggest that host metabolic pathways play a key role in host control of intracellular bacterial pathogens. In this study we explored the potential of targeting host metabolic pathways for innovative host-directed therapy (HDT) against intracellular bacterial...

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Identifiers

PMID: 34552598
DOI: 10.3389/fimmu.2021.739938
PMCID: PMC8450447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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