Article

Vinblastine Activates the AMPK–TFEB–ATG5 Autophagy Axis to Restrict Intracellular Salmonella Infection

2026-05-15

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> The rise of multidrug-resistant intracellular pathogens, such as <italic>Salmonella</italic> , poses a significant global health threat due to their ability to evade conventional antibiotics within host cells. Host-directed therapeutic (HDT) strategies that leverage the autophagy–lysosome pathway to clear these pathogens offer a promising alternative, yet r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 564cbdef-2775-587e-b972-286c311854da
DOI: 10.21203/rs.3.rs-9538087/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vinblastine Activates the AMPK–TFEB–ATG5 Autophagy Axis to Restrict Intracellular Salmonella InfectionDOI 10.21203/rs.3.rs-9538087/v1Read

Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagySemantic proximity Read

Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockadeSemantic proximity Read

Bacterial Autophagy: Offense and Defense at the Host–Pathogen InterfaceSemantic proximity Read

Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagySemantic proximity Read

Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagySemantic proximity Read

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN responseSemantic proximity Read

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antiviralsSemantic proximity Read

Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in MacrophagesSemantic proximity Read

Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling PathwaysSemantic proximity Read

Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteriaSemantic proximity Read

Autophagy, cell death, and cytokines in K. pneumoniae infection: therapeutic perspectivesSemantic proximity Read

Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infectionsSemantic proximity Read