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Article

Negative cross-resistance of a pyrethroid-resistant Drosophila mutant to Phryma leptostachya-derived haedoxan A.

Insect science - 1 Jun 2022

Qie Xingtao, Du Yuzhe, Aioub Ahmed A A, Dong Ke, Hu Zhaonong

Abstract excerpt

Voltage-gated sodium channels are the primary target of pyrethroid insecticides. Mutations in sodium channel confer knockdown resistance (kdr) to pyrethroids in various arthropod pests. Haedoxan A (HA) is the major insecticidal component from Phryma leptostachya. It has been shown that HA alters electrical responses at the Drosophila neuromuscular junction and modifies the gating properties of cockroach sodium...

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PMID: 34547832
DOI: 10.1111/1744-7917.12973

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