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Article

Early-onset familial hemiplegic migraine due to a novel SCN1A mutation.

Cephalalgia : an international journal of headache - 1 Nov 2016

Fan Chunxiang, Wolking Stefan, Lehmann-Horn Frank, Hedrich Ulrike Bs, Freilinger Tobias, Lerche Holger, Borck Guntram, Kubisch Christian, Jurkat-Rott Karin

Abstract excerpt

Introduction Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. The FHM3 subtype is caused by mutations in SCN1A, which is also the most frequent epilepsy gene encoding the voltage-gated Na+ channel NaV1.1. The aim of this study was to explore the clinical, genetic and pathogenetic features of a pure FHM3 family. Methods A three-generation family was enrolled in this...

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PMID: 26763045
DOI: 10.1177/0333102415608360
PMCID: PMC5105328

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