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Article

Extracellular matrix protein N-glycosylation mediates immune self-tolerance in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2021

Mortimer Nathan T, Fischer Mary L, Waring Ashley L, Kr Pooja, Kacsoh Balint Z, Brantley Susanna E, Keebaugh Erin S, Hill Joshua, Lark Chris, Martin Julia, Bains Pravleen, Lee Jonathan, Vrailas-Mortimer Alysia D, Schlenke Todd A

Abstract excerpt

In order to respond to infection, hosts must distinguish pathogens from their own tissues. This allows for the precise targeting of immune responses against pathogens and also ensures self-tolerance, the ability of the host to protect self tissues from immune damage. One way to maintain self-tolerance is to evolve a self signal and suppress any immune response directed at tissues that carry this signal. Here, we...

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Identifiers

PMID: 34544850
DOI: 10.1073/pnas.2017460118
PMCID: PMC8488588

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