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Article

Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles.

Developmental biology - 15 Apr 2018

Itoh Kazuyoshi, Akimoto Yoshihiro, Kondo Shu, Ichimiya Tomomi, Aoki Kazuhiro, Tiemeyer Michael, Nishihara Shoko

Abstract excerpt

T antigen (Galβ1-3GalNAcα1-Ser/Thr) is an evolutionary-conserved mucin-type core 1 glycan structure in animals synthesized by core 1 β1,3-galactosyltransferase 1 (C1GalT1). Previous studies showed that T antigen produced by Drosophila C1GalT1 (dC1GalT1) was expressed in various tissues and dC1GalT1 loss in larvae led to various defects, including decreased number of circulating hemocytes, hyper-differentiation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29499182
DOI: 10.1016/j.ydbio.2018.02.017
PMCID: PMC5898651

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