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Article

p53 Activation Effect in the Balance of T Regulatory and Effector Cell Subsets in Patients With Thyroid Cancer and Autoimmunity.

Frontiers in immunology - 1 Jan 2021

Arena Andrea, Stigliano Antonio, Belcastro Eugenia, Giorda Ezio, Rosado Maria Manuela, Grossi Armando, Assenza Maria Rita, Moretti Fabiola, Fierabracci Alessandra

Abstract excerpt

Carcinomas evade the host immune system by negatively modulating CD4+ and CD8+ T effector lymphocytes through forkhead box protein 3 (FOXP3) positive T regulatory cells' increased activity. Furthermore, interaction of the programmed cell death 1 (PD1) molecule and its ligand programmed cell death ligand 1 (PDL1) inhibits the antitumor activity of PD1+ T lymphocytes. Immunotherapy has become a powerful strategy...

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Source

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Identifiers

PMID: 34539667
DOI: 10.3389/fimmu.2021.728381
PMCID: PMC8442659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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