PD-1 Blockade Delays Tumor Growth by Inhibiting an Intrinsic SHP2/Ras/MAPK Signalling in Thyroid Cancer Cells

Abstract excerpt

<h4>Background: </h4> The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2 are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express the PD-Ls that bind PD-1 on immune cells, inhibiting their activity. Recently, PD-1 expression has also been found in cancer cells. Here, we analysed expression and functions of PD-1 in thyroid cancer (TC). <h4>Methods: </h4>: P...

Topics

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• Combined Modality Therapy
• Immune System
• Immunotherapy
• Iodine Radioisotopes
• Molecular Targeted Therapy
• Neoplasm Staging
• Thyroid Neoplasms
• Tumor Escape

Identifiers and source

Literature Corpus work

c2188b59-8931-5447-aa92-f25965a0cee0

DOI

10.21203/rs.3.rs-100301/v1