Article
Influence of p53 on anti-tumor immunity (review).
International journal of oncology - 1 Feb 2006
Bueter Marco, Gasser Martin, Lebedeva Tatiana, Benichou Gilles, Waaga-Gasser Ana Maria
Abstract excerpt
Self-tolerance and tumor-induced peripheral tolerance may be responsible for the limitations of the immune system in controlling tumor growth in cancer patients. It is known, that self-proteins are continuously processed and presented by antigen presenting cells. During development, auto-reactive T cells encountering self peptide/self-MHC complexes are being eliminated in the thymus. This process called 'negative...
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