Article
P53 and expression of immunological markers may identify early stage thyroid tumors.
Clinical & developmental immunology - 1 Jan 2013
Marcello Marjory Alana, Morari Elaine Cristina, Cunha Lucas Leite, De Nadai Silva Aline Carolina, Carraro Dirce Maria, Carvalho André Lopes, Soares Fernando Augusto, Vassallo José, Ward Laura Sterian
Abstract excerpt
BACKGROUND: Besides its major role in cell proliferation, DNA repair, and apoptosis, functional p53 protein is involved in the induction of antitumor cytotoxic-T-cell activity against carcinoma cells. We aimed to investigate p53 and immune cell markers utility as diagnostic and prognostic markers of differentiated thyroid cancer (DTC). METHODS: ACIS-III system was used to evaluate p53 and immune cell markers...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
- Child
- Female
- Gene Expression
- Genotype
- Humans
- Immunohistochemistry
- Immunophenotyping
- Lymphocytes, Tumor-Infiltrating