A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

Abstract excerpt

Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Genetic screens are often performed in transformed cell lines that poorly represent viral target cells in vivo, leading to discoveries that may not be translated to the clinic. Intestinal organoids are increasingly used to model human disease and are amenable to genetic engineering. To...

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