Article
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.
Biochemical and biophysical research communications - 9 Apr 2010
Xu Xiaojuan, Yano Masafumi, Uchinoumi Hitoshi, Hino Akihiro, Suetomi Takeshi, Ono Makoto, Tateishi Hiroki, Oda Tetsuro, Okuda Shinichi, Doi Masahiro, Kobayashi Shigeki, Yamamoto Takeshi, Ikeda Yasuhiro, Ikemoto Noriaki, Matsuzaki Masunori
Abstract excerpt
Calmodulin (CaM), one of the accessory proteins of the cardiac ryanodine receptor (RyR2), is known to play a significant role in the channel regulation of the RyR2. However, the possible involvement of calmodulin in the pathogenic process of catecholaminergic polymorphic ventricular tachycardia (CPVT) has not been investigated. In this study, we investigated the state of RyR2-bound CaM and channel dysfunctions...
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