SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.

doi:10.18632/aging.203560

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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.

Aging - 16 Sept 2021

Tripathi Utkarsh, Nchioua Rayhane, Prata Larissa G P Langhi, Zhu Yi, Gerdes Erin O Wissler, Giorgadze Nino, Pirtskhalava Tamar, Parker Erik, Xue Ailing, Espindola-Netto Jair Machado, Stenger Steffen, Robbins Paul D, Niedernhofer Laura J, Dickinson Stephanie L, Allison David B, Kirchhoff Frank, Sparrer Konstantin Maria Johannes, Tchkonia Tamar, Kirkland James L

Abstract excerpt

Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and can express a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). We recently reported that a component of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface protein, S1, can amplify the SASP of senescent cultured human cells and that a related mouse β-coronavirus,...

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PMID: 34531331
DOI: 10.18632/aging.203560
PMCID: PMC8507266

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