Article
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis.
The European respiratory journal - 1 Aug 2022
Evangelou Konstantinos, Veroutis Dimitris, Paschalaki Koralia, Foukas Periklis G, Lagopati Nefeli, Dimitriou Marios, Papaspyropoulos Angelos, Konda Bindu, Hazapis Orsalia, Polyzou Aikaterini, Havaki Sophia, Kotsinas Athanassios, Kittas Christos, Tzioufas Athanasios G, de Leval Laurence, Vassilakos Demetris, Tsiodras Sotirios, Stripp Barry R, Papantonis Argyris, Blandino Giovanni, Karakasiliotis Ioannis, Barnes Peter J, Gorgoulis Vassilis G
Abstract excerpt
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the respiratory system can progress to a multisystemic disease with aberrant inflammatory response. Cellular senescence promotes chronic inflammation, named senescence-associated secretory phenotype (SASP). We investigated whether coronavirus disease 2019 (COVID-19) is associated with cellular senescence and SASP. METHODS:...
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