Article

SARS-CoV-2 infects lung epithelial cells and induces senescence and an inflammatory response in patients with severe COVID-19

2021-01-02

Abstract excerpt

<h4>Rationale</h4> SARS-CoV-2 infection of the respiratory system can progress to a life threatening multi-systemic disease, mediated via an excess of cytokines (“cytokine storm”), but the molecular mechanisms are poorly understood. <h4>Objectives</h4> To investigate whether SARS-CoV-2 may induce cellular senescence in lung epithelial cells, leading to secretion of inflammatory cytokines, known as the senescence...

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Literature Corpus work: 1d762965-9e44-59d2-a76a-578ffe02904f
DOI: 10.1101/2021.01.02.424917

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