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Host-Specific Restriction of Avian Influenza Virus Caused by Differential Dynamics of ANP32 Family Members

1 Oct 2019

Abstract excerpt

BACKGROUND: Influenza viruses must utilize host factors to complete their lifecycle. Species-specific differences in host factors between birds and mammals mean that avian influenza viruses (AIVs) replicate well in avian hosts but not in human hosts. Acidic nuclear phosphoprotein 32 family member A (ANP32A) has been identified as the host restriction factor for the viral polymerase (vPol) activity of AIVs. The...

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PMID: 31581291
DOI: 10.1093/infdis/jiz506

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