Article
The hazards of genotype imputation in chromosomal regions under selection: A case study using the Lactase gene region.
Annals of human genetics - 1 Jan 2022
Ali Aminah T, Liebert Anke, Lau Winston, Maniatis Nikolas, Swallow Dallas M
Abstract excerpt
Although imputation of missing SNP results has been widely used in genetic studies, claims about the quality and usefulness of imputation have outnumbered the few studies that have questioned its limitations. But it is becoming clear that these limitations are real-for example, disease association signals can be missed in regions of LD breakdown. Here, as a case study, using the chromosomal region of the...
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