Article
World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection.
Human genetics - 1 Nov 2017
Liebert Anke, López Saioa, Jones Bryony Leigh, Montalva Nicolas, Gerbault Pascale, Lau Winston, Thomas Mark G, Bradman Neil, Maniatis Nikolas, Swallow Dallas M
Abstract excerpt
The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [-13910*T (rs4988235), -13907*G (rs41525747), -13915*G (rs41380347), -14009*G (rs869051967) and -14010*C (rs145946881)]. These alleles have been inferred to have spread recently and present-day frequencies have been...