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Sec23a inhibits the self-renewal of melanoma cancer stem cells via inactivation of ER-phagy

2 Mar 2022

Abstract excerpt

BACKGROUND: The genesis and developments of solid tumors, analogous to the renewal of healthy tissues, are driven by a subpopulation of dedicated stem cells, known as cancer stem cells (CSCs), that exhibit long-term clonal repopulation and self-renewal capacity. CSCs may regulate tumor initiation, growth, dormancy, metastasis, recurrence and chemoresistance. While autophagy has been proposed as a regulator of the...

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PMID: 35236368
DOI: 10.1186/s12964-022-00827-1

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