Article
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.
Arthritis and rheumatism - 1 Apr 2006
Wessels Judith A M, de Vries-Bouwstra Jeska K, Heijmans Bas T, Slagboom P Eline, Goekoop-Ruiterman Yvonne P M, Allaart Cornelia F, Kerstens Pit J S M, van Zeben Derkjen, Breedveld Ferdinand C, Dijkmans Ben A C, Huizinga Tom W J, Guchelaar Henk-Jan
Abstract excerpt
OBJECTIVE: To determine associations of methotrexate (MTX) efficacy and toxicity with single-nucleotide polymorphisms (SNPs) in genes coding for folate pathway enzymes in patients with early rheumatoid arthritis (RA). METHODS: Patients (n=205) with active RA received MTX at an initial dosage of 7.5 mg/week, which was increased to 15 mg/week and combined with folic acid (1 mg/day) after 4 weeks. If the Disease...
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