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Article

Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases.

The pharmacogenomics journal - 1 Aug 2011

Mena J P, Salazar-Páramo M, González-López L, Gámez-Nava J I, Sandoval-Ramirez L, Sánchez J D, Figuera L E, Muñoz-Valle F J, Vazquez del Mercado M, Dávalos I P

Abstract excerpt

Rheumatoid arthritis (RA) is the prototype of the rheumatic diseases worldwide. Methotrexate (MTX) is the drug of first choice in the treatment of this disease due to its immunosuppressant effect. However, side events are present in 30% of the patients. The C677T and A1298C polymorphisms of the m...

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Source

Identifiers

PMID: 20514079
DOI: 10.1038/tpj.2010.32

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20514079-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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