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Genetic Alterations in Benign Adrenal Tumors

30 Apr 2022

Abstract excerpt

The genetic basis of most types of adrenal adenomas has been elucidated over the past decade, leading to the association of adrenal gland pathologies with specific molecular defects. Various genetic studies have established links between variants affecting the protein kinase A (PKA) signaling pathway and benign cortisol-producing adrenal lesions. Specifically, genetic alterations in GNAS, PRKAR1A, PRKACA, PRKACB,...

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PMID: 35625779
DOI: 10.3390/biomedicines10051041

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