Article
Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.
The Journal of clinical endocrinology and metabolism - 1 Sept 2016
Ronchi Cristina L, Di Dalmazi Guido, Faillot Simon, Sbiera Silviu, Assié Guillaume, Weigand Isabel, Calebiro Davide, Schwarzmayr Thomas, Appenzeller Silke, Rubin Beatrice, Waldmann Jens, Scaroni Carla, Bartsch Detlef K, Mantero Franco, Mannelli Massimo, Kastelan Darko, Chiodini Iacopo, Bertherat Jerome, Reincke Martin, Strom Tim M, Fassnacht Martin, Beuschlein Felix
Abstract excerpt
CONTEXT: Adrenocortical adenomas (ACAs) are among the most frequent human neoplasias. Genetic alterations affecting the cAMP/protein kinase A signaling pathway are common in cortisol-producing ACAs, whereas activating mutations in the gene encoding β-catenin (CTNNB1) have been reported in a subset of both benign and malignant adrenocortical tumors. However, the molecular pathogenesis of most ACAs is still largely...
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