Article
Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer.
Cancer communications (London, England) - 1 Dec 2021
Wu Chong, Zhu Jingjing, King Austin, Tong Xiaoran, Lu Qing, Park Jong Y, Wang Liang, Gao Guimin, Deng Hong-Wen, Yang Yaohua, Knudsen Karen E, Rebbeck Timothy R, Long Jirong, Zheng Wei, Pan Wei, Conti David V, Haiman Christopher A, Wu Lang
Abstract excerpt
BACKGROUND: DNA methylation and gene expression are known to play important roles in the etiology of human diseases such as prostate cancer (PCa). However, it has not yet been possible to incorporate information of DNA methylation and gene expression into polygenic risk scores (PRSs). Here, we aimed to develop and validate an improved PRS for PCa risk by incorporating genetically predicted gene expression and DNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.