Article
Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience.
Genetic epidemiology - 1 Apr 2011
Bennett Siiri N, Caporaso Neil, Fitzpatrick Annette L, Agrawal Arpana, Barnes Kathleen, Boyd Heather A, Cornelis Marilyn C, Hansel Nadia N, Heiss Gerardo, Heit John A, Kang Jae Hee, Kittner Steven J, Kraft Peter, Lowe William, Marazita Mary L, Monroe Kristine R, Pasquale Louis R, Ramos Erin M, van Dam Rob M, Udren Jenna, Williams Kayleen
Abstract excerpt
Genome-wide association study (GWAS) consortia and collaborations formed to detect genetic loci for common phenotypes or investigate gene-environment (G*E) interactions are increasingly common. While these consortia effectively increase sample size, phenotype heterogeneity across studies represents a major obstacle that limits successful identification of these associations. Investigators are faced with the...
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