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Article

GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing.

Communications biology - 11 Aug 2022

Mathur Ravi, Fang Fang, Gaddis Nathan, Hancock Dana B, Cho Michael H, Hokanson John E, Bierut Laura J, Lutz Sharon M, Young Kendra, Smith Albert V, Silverman Edwin K, Page Grier P, Johnson Eric O

Abstract excerpt

Genome-wide association studies (GWAS) have made impactful discoveries for complex diseases, often by amassing very large sample sizes. Yet, GWAS of many diseases remain underpowered, especially for non-European ancestries. One cost-effective approach to increase sample size is to combine existing cohorts, which may have limited sample size or be case-only, with public controls, but this approach is limited by...

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PMID: 35953715
DOI: 10.1038/s42003-022-03738-6
PMCID: PMC9372058

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