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Article

Clinical Reasoning: A Middle-aged Man With Progressive Gait Abnormalities.

Neurology - 14 Dec 2021

Lin Junyu, Hou Yanbing, Shang Huifang

Abstract excerpt

Progressive spastic paraplegia is the core symptom of hereditary spastic paraplegias (HSPs), a group of monogenic disorders characterized pathologically by degeneration of the corticospinal tract and dorsal column and leading to irreversible neurologic deficits. However, acquired causes, such as structural, vascular, inflammatory, infectious, metabolic, toxic, neurodegenerative, and iatrogenic causes, can also...

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PMID: 34504025
DOI: 10.1212/WNL.0000000000012756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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