Article
Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
International journal of molecular sciences - 26 Aug 2021
Brandherm Lukas, Kobaš Antonio Mario, Klöhn Mara, Brüggemann Yannick, Pfaender Stephanie, Rassow Joachim, Kreimendahl Sebastian
Abstract excerpt
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the causative agent of the COVID19 pandemic. The SARS-CoV-2 genome encodes for a small accessory protein termed Orf9b, which targets the mitochondrial outer membrane protein TOM70 in infected cells. TOM70 is involved in a signaling cascade that ultimately leads to the induction of type I interferons (IFN-I). This cascade depends on the recruitment of...
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