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Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

31 Oct 2023

Abstract excerpt

ABSTRACT Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that plays a central role in the folding and maturation of a large array of client proteins. In the unicellular parasite Leishmania , the etiological agent of the neglected tropical disease leishmaniasis, treatment with HSP90 inhibitors leads to differentiation from promastigote to amastigote stage, resembling the effects of...

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PMID: 37905935
DOI: 10.1128/spectrum.02960-23

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