Article
Mitochondrial chaperon TNF-receptor- associated protein 1 as a novel apoptotic regulator conferring susceptibility to Pneumocystis jirovecii pneumonia.
Frontiers in immunology - 1 Jan 2024
Amali Aseervatham Anusha, Paramasivam Kathirvel, Huang Chiung Hui, Joshi Abhinav, Hirpara Jayshree L, Ravikumar Sharada, Sam Qi Hui, Tan Rachel Ying Min, Tan Zhaohong, Kumar Dilip, Neckers Leonard M, Pervaiz Shazib, Foo Roger, Chan Candice Y Y, Zhu Jin, Lee Cheryl, Chai Louis Yi Ann
Abstract excerpt
Molecular chaperons stabilize protein folding and play a vital role in maintaining tissue homeostasis. To this intent, mitochondrial molecular chaperons may be involved in the regulation of oxidative phosphorylation and apoptosis during stress events such as infections. However, specific human infectious diseases relatable to defects in molecular chaperons have yet to be identified. To this end, we performed...
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