GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation.

doi:10.1007/s00432-021-03769-2

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Article

GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation.

Journal of cancer research and clinical oncology - 1 Jan 2022

Jurkovic Mlakar Simona, Uppugunduri Satyanarayana Chakradhara Rao, Nava Tiago, Mlakar Vid, Golay Hadrien, Robin Shannon, Waespe Nicolas, Rezgui Mohamed Aziz, Chalandon Yves, Boelens Jaap Jan, Bredius Robert G M, Dalle Jean-Hugues, Peters Christina, Corbacioglu Selim, Bittencourt Henrique, Krajinovic Maja, Ansari Marc

Abstract excerpt

PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid...

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Identifiers

PMID: 34499222
DOI: 10.1007/s00432-021-03769-2
PMCID: PMC8752561

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