Myeloid malignancies with translocation t(4;12)(q11-13;p13): molecular landscape, clonal hierarchy and clinical outcomes.

doi:10.1111/jcmm.16895

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Article

Myeloid malignancies with translocation t(4;12)(q11-13;p13): molecular landscape, clonal hierarchy and clinical outcomes.

Journal of cellular and molecular medicine - 1 Oct 2021

Parinet Vincent, Chapiro Elise, Bidet Audrey, Gaillard Baptiste, Maarek Odile, Simon Laurence, Lefebvre Christine, Defasque Sabine, Mozziconacci Marie-Joelle, Quinquenel Anne, Decamp Matthieu, Lifermann François, Ali-Ammar Nadia, Maillon Agathe, Baron Marine, Martin Mélanie, Struski Stéphanie, Penther Dominique, Micol Jean-Baptiste, Auger Nathalie, Bilhou-Nabera Chrystèle, Martignoles Jean-Alain, Tondeur Sylvie, Nguyen-Khac Florence, Hirsch Pierre, Roos-Weil Damien

Abstract excerpt

Translocation t(4;12)(q11-13;p13) is a recurrent but very rare chromosomal aberration in acute myeloid leukaemia (AML) resulting in the non-constant expression of a CHIC2/ETV6 fusion transcript. We report clinico-biological features, molecular characteristics and outcomes of 21 cases of t(4;12) including 19 AML and two myelodysplastic syndromes (MDS). Median age at the time of t(4;12) was 78 years (range, 56-88)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34492730
DOI: 10.1111/jcmm.16895
PMCID: PMC8505829

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