Article
A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.
Genes, chromosomes & cancer - 1 Apr 2024
Mavridou Elena, Lema Fernandez Anair Graciela, Nardelli Carlotta, Pierini Valentina, Quintini Martina, Arniani Silvia, Di Giacomo Danika, Crescenzi Barbara, Matteucci Caterina, Sambani Constantina, Mecucci Cristina
Abstract excerpt
In myeloid neoplasms, both fusion genes and gene mutations are well-established events identifying clinicopathological entities. In this study, we present a thus far undescribed t(X;21)(p11.4;q22.12) in five cases with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The translocation was isolated or accompanied by additional changes. It did not generate any fusion gene or gene deregulation by...
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