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Article

The signs of negative selection in IGHV framework regions are associated with worse overall survival of chronic lymphocytic leukemia patients.

Leukemia research - 1 Nov 2021

Abramenko Iryna, Bilous Nadia, Chumak Anatoliy, Kryachok Iryna, Fedorenko Zoya, Martina Zoya, Dyagil Iryna

Abstract excerpt

The mutational status of the variable region of the immunoglobulin heavy chain (IGHV) genes remains the most significant prognostic factor in chronic lymphocytic leukemia (CLL) patients. However, the groups of mutated (M) and unmutated (UM) patients are also heterogeneous, and additional markers are used for a more accurate prognosis. The aim of our work was to determine the prognostic value of the signs of...

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Identifiers

PMID: 34492598
DOI: 10.1016/j.leukres.2021.106686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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