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Article

Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 2003

Vasconcelos Yuri, Davi Frédéric, Levy Vincent, Oppezzo Pablo, Magnac Christian, Michel Ariane, Yamamoto Mihoko, Pritsch Otto, Merle-Béral Hélène, Maloum Karim, Ajchenbaum-Cymbalista Florence, Dighiero Guillaume

Abstract excerpt

PURPOSE: Rai's and Binet's staging systems have contributed significantly to the identification of major prognostic groups in chronic lymphocytic leukemia (CLL), though they fail to accurately predict disease progression at the individual level. Biologic factors, such as the mutational status of the immunoglobulin heavy-chain variable genes (VH, cytogenetics, CD38 expression, and some serum markers, have recently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14581416
DOI: 10.1200/JCO.2003.02.134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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