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Article

98% IGHV gene identity is the optimal cutoff to dichotomize the prognosis of Chinese patients with chronic lymphocytic leukemia.

Cancer medicine - 1 Feb 2020

Shi Ke, Sun Qian, Qiao Chun, Zhu Huayuan, Wang Li, Wu Jiazhu, Wang Lili, Fu Jianxin, Young Ken H, Fan Lei, Xia Yi, Xu Wei, Li Jianyong

Abstract excerpt

Immunoglobulin heavy chain variable region (IGHV) mutational status has been an important prognostic factor for chronic lymphocytic leukemia (CLL) for decades. Patients with unmutated IGHV (≥98% identity to the germline sequence) have inferior prognosis and tend to carry unfavorable genetic markers compared to those with mutated IGHV (<98% identity to the germline sequence). However, 98% as the cutoff for IGHV...

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Identifiers

PMID: 31849198
DOI: 10.1002/cam4.2788
PMCID: PMC6997101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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