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Article

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

27 Sept 2018

Abstract excerpt

Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences. Considering this, we assessed prognosis separately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015 patients, hypothesizing that the relative significance of relevant indicators may differ...

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PMID: 30262567
DOI: 10.3324/haematol.2018.195032

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