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Article

A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema.

The Journal of allergy and clinical immunology - 1 Nov 2007

Schulz Florian, Marenholz Ingo, Fölster-Holst Regina, Chen Christiane, Sternjak Alexander, Baumgrass Ria, Esparza-Gordillo Jorge, Grüber Christoph, Nickel Renate, Schreiber Stefan, Stoll Monika, Kurek Michael, Rüschendorf Franz, Hubner Norbert, Wahn Ulrich, Lee Young-Ae

Abstract excerpt

BACKGROUND: IL-31 is a novel cytokine that, when overexpressed in transgenic mice, induces severe itching dermatitis resembling human eczema. OBJECTIVE: We aimed to evaluate the importance of polymorphisms in the human IL-31 gene (IL31) in the genetic susceptibility to eczema. METHODS: We sequenced the entire IL-31 gene, including the promoter region, and determined the haplotype structure. Single nucleotide...

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Identifiers

PMID: 17900679
DOI: 10.1016/j.jaci.2007.07.065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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